Temperature and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19

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DoctorMu
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Re: Temperature and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19

Post by DoctorMu » Thu Jun 11, 2020 12:05 am

Ptarmigan wrote:
Tue Jun 02, 2020 8:51 pm
Does the pathogenesis of SAR-CoV-2 virus decrease at high-altitude?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175867/
Our epidemiological analysis of the Covid-19 pandemic clearly indicates a decrease of prevalence and impact of SARS-CoV-2 infection in populations living at altitude of above 3,000 masl. The reason for decreased severity of the global COVID-19 outbreak at high altitude could relate to both environmental and physiological factors.

Environmental factors may influence the virulence of SARS-CoV-2 at high-altitude. Indeed, a high-altitude environment is characterized by drastic changes in temperature between night and day, air dryness, and high levels of ultraviolet (UV) light radiation (United-States-Environmental-Protection-Agency 2017). In particular UV light radiation A (UVA) and B (UVB) is well known to be capable of producing alterations in the molecular bonds of the DNA and RNA, and thus UV radiation at high-altitude may act as a natural sanitizer (Andrade 2020; Zubieta-Calleja 2020a; Zubieta-Calleja and Zubieta-DeUrioste 2017). In relation to SARS-CoV-2, while complete disinfection cannot be achieved by UVA and UVB, these radiations should shorten the half-life of any given virus (Andrade 2020; Zubieta-Calleja 2020b). It is clear that, all together, these factors may dramatically reduce the “survival” capacity of the virus at high-altitude, and therefore its virulence. Finally, due to the lower density of air and greater distance between molecules at high-altitude, the size of the airborne virus inoculum must be smaller than at sea level.

Although the data of the present study suggest a strongly decreased pathogenicity of SARS-CoV-2 in high-altitude, there is yet no evidence of an underlying physiological mechanisms that could affect to severity of infection. However, there is a positive correlation between the infection rate of SARS-CoV-1 and ACE2 in pulmonary epithelial cells. Importantly both SARS-CoV-1 and SARS-CoV-2 bind to ACE2 (Lu et al. 2020; Rothan and Byrareddy 2020; van Doremalen et al., 2020), and thus a putative decrease of ACE2 expression in pulmonary endothelia in high-altitude inhabitant could represent a physiological protective for the severe and often lethal pulmonary edema.

Another factor is that people living at high altitude, especially those who are children of high altitude dwellers have adapted their lungs and pulmonary circulation and have a much higher capacity than se level resident. Their adaptations also make them less susceptible to lung edema.

Another consequence of increased HIF-1 at altitude is an increase in AMP kinase which can fight inflammation. Interesting news indeed!

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Re: Temperature and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19

Post by jasons2k » Fri Sep 04, 2020 7:10 am

Check out the “curve” in Sweden these days since the news won’t report on it ;)

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DoctorMu
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Re: Temperature and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19

Post by DoctorMu » Wed Sep 23, 2020 12:33 pm

Equivalent of 200K US dead and 5.1% economic contraction. Only 5% have tested positive. Not that good. It would be worse, but most Swedes live alone. Housing is through the roof.

Norway has the equivalent of 10K dead, same economic impact, and schools, shops are completely reopened now in Norway.

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Re: Temperature and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19

Post by unome » Mon Nov 23, 2020 8:46 pm

I hope everyone has a safe Thanksgiving - I feel the need to tell you 1 of my cousins died from COVID-19 pneumonia on the 9th & today my youngest brother was just admitted to the hospital with the same, oxygen level in the 80s at the time, but better, so far. His entire family has either tested positive or has symptoms & for whatever reason (it escapes me) they have not all tested... tests are available.

The kind & overworked ICU staff held a phone to my cousin's ear so his loved ones could tell them they loved him one last time and say goodbye. He may not have heard them by then.

They are both in northern states, where temps are colder, people are staying inside more often now, homes are better insulated so less fresh air flow from the outside. But, it can happen anywhere.

Please be safe, please wear a (good) mask, please know that sharing a dinner (or whatever) isn't worth your loved one's life - it affects so many more people than just yourself...

We can get through this, but we need to be smart - stay safe y'all - unome

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Re: Temperature and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19

Post by BlueJay » Tue Nov 24, 2020 10:26 am

I am sorry to hear this news, unome. Wishing strength for your family.

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Re: Temperature and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19

Post by Katdaddy » Tue Nov 24, 2020 11:30 am

I am so very sorry for your loss unome. Also wishing strength for your family doing this very rough time.

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Re: Temperature and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19

Post by DoctorMu » Tue Nov 24, 2020 6:50 pm

Really sorry to hear that, unome.

Because of new COVID travel restrictions, our son won't be able to return home from Minnesota. Unfortunately, it's the wise move.

Everyone stay safe and healthy!


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